Polyurea with headache

29 year woman with 1 month history of headache , increased thrist and urinary frequency.
Urinary out put over 24 hours was 8 liters.Fluid deprivation test was performed with following
results:

 Time                              Serum Osm                  Urine Osm                    Serum ADH             Urine output

Baseline                           144                              80                                 2                                  -

1 hour                               147                             80                                  2                              600

2 hour                               150                              80                                  2                               500


Q.        What is the diagnosis?
Q.         Treatment?


Answere:    This patient has central diabetic inspidus and his defect seems to be severe.The D/D should include both central and nephrogenic dI, as well psychogenic polydipsia and diuretic use.

Desmopressin( Vasopressin) is the prefered teatment.








Vasopressin