Goodpasture’s disease is the most aggressive and rapidly progressive glomerulonephritis
encountered in clinical practice. Crescentic nephritis may be accompanied by lifethreatening
pulmonary hemorrhage.. Treatment with cyclophosphamide, steroids, and plasma exchange can arrest the
disease, but renal damage may be irrecoverabl
. In small-vessel vasculitis, the mainstay of therapy consists of corticosteroids and
cyclophosphamide.. In antineutrophil cytoplasmic autoantibody (ANCA) vasculitis, plasma exchange is
presently recommended in addition to corticosteroids and cyclophosphamide for
patients presenting with advanced renal failure and/or pulmonary hemorrhage.. A high rate of venous thromboembolism has been reported in ANCA vasculitis, with
about 10% of patients developing symptomatic events.
encountered in clinical practice. Crescentic nephritis may be accompanied by lifethreatening
pulmonary hemorrhage.. Treatment with cyclophosphamide, steroids, and plasma exchange can arrest the
disease, but renal damage may be irrecoverabl
. In small-vessel vasculitis, the mainstay of therapy consists of corticosteroids and
cyclophosphamide.. In antineutrophil cytoplasmic autoantibody (ANCA) vasculitis, plasma exchange is
presently recommended in addition to corticosteroids and cyclophosphamide for
patients presenting with advanced renal failure and/or pulmonary hemorrhage.. A high rate of venous thromboembolism has been reported in ANCA vasculitis, with
about 10% of patients developing symptomatic events.
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